What each boss actually hits you with, and which rune answers it. Every attack in this game carries a list of damage types, and those types are what your damage reduction runes key off. Pick the ones that match what you are fighting and you take measurably less; pick the wrong one and the slot does nothing.

Built from 108 boss encounters in the 0630 game files. There are no HP or ATK numbers here on purpose: boss stats scale with your chapter and account, so any single figure would be wrong for almost everyone.

1What every boss doesthe two runes that are almost always right

Damage typeBossesRune that reduces it
WeaponAttack108 of 108100%no rune reduces this
BasicAttack107 of 10899%Basic Attack DMG Reduction
PhysicalDamage100 of 10893%Physical DMG Reduction
RageAttack93 of 10886%no rune reduces this
MagicalDamage30 of 10828%no rune reduces this
Skill29 of 10827%no rune reduces this
CounterAttack12 of 10811%Counter Attack DMG Reduction
Fire11 of 10810%Fire DMG Reduction
ComboAttack9 of 1088%Combo Attack DMG Reduction
Ice9 of 1088%Ice DMG Reduction
Icicle2 of 1082%no rune reduces this
Poison2 of 1082%no rune reduces this
Wound2 of 1082%no rune reduces this
The default pair. Basic Attack DMG Reduction works on 107 of 108 bosses and Physical DMG Reduction on 100. If you are not building for a specific fight, those two are the safe slots.
Lightning DMG Reduction is dead weight against bosses. Not one of the 108 bosses deals Lightning damage, so that rune reduces nothing in a boss fight. It can still matter against ordinary enemies.

2What no rune stopsplan around these instead

BehaviourBossesWhat it means
Restoration9heals itself
TrueDamage8skips your DEF and every damage reduction
Lifesteal7heals from the damage it deals
Shield6shields itself
Thorns5damages you when you hit it
IgnoreShield4goes through shields
RampantRage1builds rage faster
Damage reduction will not save you from these. A boss that heals needs you to out-damage the healing, and one that hits through shields makes shield skills a waste of a slot in that fight.

3Crimson Nightmarethe saga event, stage by stage

The event runs three stages, 9 boss fights in all. Only 7 of them are against a creature the game itself tags as a Boss, so DMG vs Boss does nothing in the other 2. The badge on each fight says which is which. Ice only comes from Stage 1, so Ice DMG Reduction earns its slot there and nowhere else in this event.

Stage 13 boss fights, 10 encounters
Boss fights
Clown FreakBOSSBasicAttackPhysicalDamageRageAttackSkeleton DragonBOSSBasicAttackIceMagicalDamagePhysicalDamageRageAttackVallatioBOSSBasicAttackPhysicalDamageRageAttackWound
Also in this stage
Zombie ClownBasicAttackPhysicalDamageGhost KnightBasicAttackCleavePhysicalDamageSkeleton RingmasterBasicAttackMagicalDamageRageAttack
Stage 23 boss fights, 12 encounters
Boss fights
KitsuraBOSSBasicAttackPhysicalDamageRageAttackStumpyBOSSBasicAttackPhysicalDamageRageAttackThe MonsterELITEBasicAttackPhysicalDamageRageAttack
Also in this stage
Living TreeBasicAttackPhysicalDamageWolf SpiderBasicAttackPhysicalDamageSkeleton ArcherBasicAttackPhysicalDamage
Stage 33 boss fights, 12 encounters
Boss fights
HydraNORMALBasicAttackPhysicalDamageTrueDamageRed DemonBOSSBasicAttackIgnoreShieldPhysicalDamageTrueDamageDemon Lord VallatioBOSSBasicAttackPhysicalDamageRageAttackWound
Also in this stage
Fallen AdventurerBasicAttackPhysicalDamageShurikenSkeleton KnightBasicAttackPhysicalDamageImpBasicAttackPhysicalDamage

4Crystal Expeditionthe saga event, stage by stage

The event runs three stages, 9 boss fights in all. Only 7 of them are against a creature the game itself tags as a Boss, so DMG vs Boss does nothing in the other 2. The badge on each fight says which is which. Ice only comes from Stage 3, so Ice DMG Reduction earns its slot there and nowhere else in this event.

Stage 13 boss fights, 10 encounters
Boss fights
Giant SlimeBOSSBasicAttackComboAttackCounterAttackPhysicalDamageCorvusBOSSBasicAttackPhysicalDamageRageAttackGoblin OgreBOSSBasicAttackPhysicalDamageRageAttack
Also in this stage
SlimeBasicAttackPhysicalDamageWolfBasicAttackPhysicalDamageCave SpiderBasicAttackPhysicalDamage
Stage 23 boss fights, 13 encounters
Boss fights
Haunted TreeBOSSBasicAttackPhysicalDamageRageAttackBansheeELITEBasicAttackMagicalDamagePhysicalDamageRageAttackAncient MyconidBOSSBasicAttackPhysicalDamage
Also in this stage
ShroomBasicAttackPhysicalDamageLiving TreeBasicAttackPhysicalDamageDesert HornetBasicAttackPhysicalDamage
Stage 33 boss fights, 12 encounters
Boss fights
Crystal ConstructBOSSBasicAttackPhysicalDamageRageAttackThe First SeekerELITEBasicAttackPhysicalDamageRageAttackCrysalith WyrmBOSSBasicAttackIceMagicalDamagePhysicalDamageRageAttack
Also in this stage
Crystal SlimeBasicAttackIceIcicleMagicalDamagePhysicalDamageFallen AdventurerBasicAttackPhysicalDamageShurikenGhost KnightBasicAttackCleavePhysicalDamage

5City of Goldthe saga event, stage by stage

The event runs three stages, 9 boss fights in all. Only 5 of them are against a creature the game itself tags as a Boss, so DMG vs Boss does nothing in the other 4. The badge on each fight says which is which. Fire only comes from Stage 1, so Fire DMG Reduction earns its slot there and nowhere else in this event.

Stage 13 boss fights, 10 encounters
Boss fights
IlluminaBOSSBasicAttackMagicalDamagePhysicalDamageRageAttackTrueDamageRedbeard, also called BlackbeardELITEBasicAttackPhysicalDamageRageAttackGoblin MageBOSSBasicAttackFireMagicalDamageRageAttack
Also in this stage
WolfBasicAttackPhysicalDamagePirateBasicAttackPhysicalDamageGoblin GruntBasicAttackPhysicalDamage
Stage 23 boss fights, 12 encounters
Boss fights
Stone ElementalELITEBasicAttackCounterAttackPhysicalDamageThornsGoblin BallistaELITEPhysicalDamageRageAttackHydra TyrantNORMALBasicAttackPhysicalDamageTrueDamage
Also in this stage
Water SpriteBasicAttackPhysicalDamageGoblin HunterBasicAttackPhysicalDamageSkyshroomBasicAttackPhysicalDamage
Stage 33 boss fights, 12 encounters
Boss fights
MinotaurBOSSBasicAttackPhysicalDamageRageAttackCity GuardianBOSSBasicAttackPhysicalDamageRageAttackThe Golden KingBOSSBasicAttackComboAttackCounterAttackPhysicalDamageRageAttack
Also in this stage
ScorpionBasicAttackPhysicalDamageGolden WarriorBasicAttackPhysicalDamageMummy WarriorBasicAttackPhysicalDamage

6Magma Mountain: Eruptionthe saga event, stage by stage

The event runs three stages, 9 boss fights in all. Only 5 of them are against a creature the game itself tags as a Boss, so DMG vs Boss does nothing in the other 4. The badge on each fight says which is which. All three stages carry Fire, so Fire DMG Reduction is the event pick on top of your usual Physical.

Stage 13 boss fights, 12 encounters
Boss fights
Undead CommanderELITEBasicAttackComboAttackCounterAttackPhysicalDamageRageAttackDracoBOSSBasicAttackFireMagicalDamagePhysicalDamageRageAttackRampantRageSkeleton KingBOSSBasicAttackComboAttackCounterAttackPhysicalDamageRageAttack
Also in this stage
Skeleton WarriorBasicAttackPhysicalDamageSkeleton MageBasicAttackMagicalDamageRageAttackSkeleton ArcherBasicAttackPhysicalDamageFire SpriteBasicAttackFireMagicalDamage
Stage 23 boss fights, 14 encounters
Boss fights
Big FootELITEBasicAttackPhysicalDamageRageAttackTribal ChiefELITEBasicAttackFireMagicalDamagePhysicalDamageRageAttackMagma ElementalBOSSBasicAttackCounterAttackPhysicalDamageThorns
Also in this stage
Cave SpiderBasicAttackPhysicalDamageDesert HornetBasicAttackPhysicalDamageTribal WarriorBasicAttackPhysicalDamageScorpionBasicAttackPhysicalDamage
Stage 33 boss fights, 14 encounters
Boss fights
Goblin MageBOSSBasicAttackFireMagicalDamageRageAttackRed SlimeELITEBasicAttackLifestealPhysicalDamageRageAttackRestorationMolten ConstructBOSSBasicAttackFireMagicalDamagePhysicalDamageRageAttack
Also in this stage
Goblin GruntBasicAttackPhysicalDamageSkeleton MinerBasicAttackPhysicalDamageFire SpriteBasicAttackFireMagicalDamageScorpionBasicAttackPhysicalDamage

7Every boss108 encounters flagged as a boss

DMG vs Boss only works on the ones tagged BOSS. The rune checks the creature you are hitting, not whether the fight is a boss fight, and only 61 of these 108 encounters contain a creature the game tags as a Boss. In the other 47 the rune adds nothing at all, and neither does it against a boss's escorts: an ELITE does not count. The same is true in reverse for DMG Reduction vs Boss, which only reduces damage from a BOSS-tagged attacker.
BossTaggedAlso dealsRunes that help
AkkorokamuiELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Akkorokamui (Hard)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Ancient ConstructBOSSPhysicalDamageRageAttackShieldDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Ancient Construct (Chaos)BOSSPhysicalDamageRageAttackShieldDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Ancient Construct (Hard)BOSSPhysicalDamageRageAttackShieldDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Ancient Myconid (Crystal Expedition)BOSSPhysicalDamageDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
AnubisBOSSIgnoreShieldPhysicalDamageTrueDamageDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Anubis (Chaos)BOSSIgnoreShieldLifestealPhysicalDamageRestorationTrueDamageDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Anubis (Hard)BOSSIgnoreShieldLifestealPhysicalDamageRestorationTrueDamageDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
BansheeELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Banshee (Crystal Expedition)ELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Banshee (Hard)ELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
BastetELITEComboAttackPhysicalDamageRageAttackBasic Attack DMG Reduction, Combo Attack DMG Reduction, Physical DMG Reduction
Bastet (Hard)ELITEComboAttackPhysicalDamageRageAttackBasic Attack DMG Reduction, Combo Attack DMG Reduction, Physical DMG Reduction
Big Foot (Magma Mountain)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
City GuardianBOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Clown Freak (Crimson Nightmare)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Corvus (Crystal Expedition)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Crysalith Wyrm (Crystal Expedition)BOSSIceMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Crystal Construct (Crystal Expedition)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Demon Lord Vallatio (Crimson Nightmare)BOSSPhysicalDamageRageAttackWoundDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Draco (Magma Mountain)BOSSFireMagicalDamagePhysicalDamageRageAttackRampantRageDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction, Physical DMG Reduction
Drowned CaptainELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Drowned Captain (Hard)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Gecko Dinosaur 1BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Gecko Dinosaur 2BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Gecko Dinosaur 3BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Giant Slime (Crystal Expedition)BOSSComboAttackCounterAttackPhysicalDamageDMG vs Boss, Basic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Goblin Ballista (City of Gold)ELITEPhysicalDamageRageAttackPhysical DMG Reduction
Goblin Engineer Goblin BallistaELITEPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
Goblin Engineer Goblin Ballista (Hard)ELITEPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
Goblin MageELITEFireMagicalDamageRageAttackBasic Attack DMG Reduction, Fire DMG Reduction
Goblin Mage (City of Gold)BOSSFireMagicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction
Goblin Mage (Hard)ELITEFireMagicalDamageRageAttackBasic Attack DMG Reduction, Fire DMG Reduction
Goblin OgreBOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Goblin Ogre (Chaos)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Goblin Ogre (Crystal Expedition)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Goblin Ogre (Hard)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Haunted Tree (Crystal Expedition)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Hydra (Crimson Nightmare)NORMALPhysicalDamageTrueDamageBasic Attack DMG Reduction, Physical DMG Reduction
Hydra Tyrant (City of Gold)NORMALPhysicalDamageTrueDamageBasic Attack DMG Reduction, Physical DMG Reduction
Hydra Tyrant (Hard)NORMALPhysicalDamageTrueDamageBasic Attack DMG Reduction, Physical DMG Reduction
Ice DragonBOSSIceMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Ice Dragon (Chaos)BOSSIceIcicleMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Ice Dragon (Hard)BOSSIceIcicleMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
IfritBOSSFireMagicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction
Ifrit (Chaos)BOSSFireMagicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction
Ifrit (Hard)BOSSFireMagicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction
Illumina (City of Gold)BOSSMagicalDamagePhysicalDamageRageAttackTrueDamageDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Kitsura (Crimson Nightmare)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
KrakenBOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Kraken (Chaos)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Kraken (Hard)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
LeviathanBOSSPhysicalDamageRageAttackShieldDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Leviathan (Chaos)BOSSPhysicalDamageRageAttackShieldDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Leviathan (Hard)BOSSPhysicalDamageRageAttackShieldDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Magma Elemental (Hard)BOSSCounterAttackPhysicalDamageThornsDMG vs Boss, Basic Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Magma Elemental (Magma Mountain)BOSSCounterAttackPhysicalDamageThornsDMG vs Boss, Basic Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Magma Elemental (Magma Mountain)BOSSCounterAttackPhysicalDamageThornsDMG vs Boss, Basic Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
MedusaELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Medusa (Hard)ELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Minotaur (Chaos)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Minotaur (City of Gold)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Minotaur (Hard)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Molten Construct (Hard)BOSSFireMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction, Physical DMG Reduction
Molten Construct (Magma Mountain)BOSSFireMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction, Physical DMG Reduction
Molten Construct (Magma Mountain)BOSSFireMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Fire DMG Reduction, Physical DMG Reduction
Mummy General Mummy Warrior x2ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Mummy General Mummy Warrior x2 (Hard)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Pirate CaptainELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Pirate Captain (Hard)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Red Demon (Crimson Nightmare)BOSSIgnoreShieldPhysicalDamageTrueDamageDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Red SlimeELITELifestealPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
Red Slime (Hard)ELITELifestealPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
Red Slime (Magma Mountain)ELITELifestealPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
Redbeard, also called Blackbeard (City of Gold)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
SirenELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Siren (Hard)ELITEMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
Skeleton Commander (Hard) x2ELITEComboAttackCounterAttackPhysicalDamageRageAttackBasic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Skeleton Commander (Undead Commander in Magma Mountain)ELITEComboAttackCounterAttackPhysicalDamageRageAttackBasic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Skeleton Dragon (Crimson Nightmare)BOSSIceMagicalDamagePhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Skeleton KingBOSSComboAttackCounterAttackPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Skeleton King (Chaos)BOSSComboAttackCounterAttackPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Skeleton King (Hard)BOSSComboAttackCounterAttackPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Stone ElementalELITECounterAttackPhysicalDamageThornsBasic Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Stone Elemental (Hard)ELITECounterAttackPhysicalDamageRageAttackThornsBasic Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
StumpyBOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Stumpy (Chaos)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Stumpy (Crimson Nightmare)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Stumpy (Hard)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
The AbominationBOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
The Abomination (Chaos)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
The Abomination (Hard)BOSSPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
The First Seeker (Crystal Expedition)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
The Golden King (City of Gold)BOSSComboAttackCounterAttackPhysicalDamageRageAttackDMG vs Boss, Basic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
The Monster (Crimson Nightmare)ELITEPhysicalDamageRageAttackBasic Attack DMG Reduction, Physical DMG Reduction
The Sewer DwellerELITEMagicalDamagePoisonRageAttackBasic Attack DMG Reduction
The Sewer Dweller (Hard)ELITEMagicalDamagePoisonRageAttackBasic Attack DMG Reduction
The SludgeELITELifestealPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
The Sludge (Hard)ELITELifestealPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
Tribal Chief (Magma Mountain)ELITEFireMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Fire DMG Reduction, Physical DMG Reduction
Troll Cultist x3ELITEIceMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Troll Cultist x3 (Hard)ELITEIceMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
VallatioBOSSPhysicalDamageRageAttackWoundDMG vs Boss, Basic Attack DMG Reduction, Physical DMG Reduction
Wolf PackELITEPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Wolf Pack (Hard)ELITEPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
YetiELITEIceMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Yeti (Hard)ELITEIceMagicalDamagePhysicalDamageRageAttackBasic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction

8Guild Raid and Dojoone opponent, and it is not a boss

These two modes put you in front of a single enemy, and the game files treat that enemy as an ordinary creature: not one of them is tagged Boss, and neither mode flags its fight as a boss fight. So DMG vs Boss and DMG Reduction vs Boss are both worth nothing here, however much the enemy looks the part.

Guild Raidthree targets, one per season
Chain WardenNORMALTrueDamageHydraNORMALTrueDamageOgre OppressorNORMALTrueDamage
Damage reduction does nothing in a raid. All six of their attacks are TrueDamage, and that tag skips the whole mitigation step: your DEF is never read and not one damage reduction applies, the boss ones included. What still works is anything that stops a hit rather than shrinking it: a shield absorbs it and an active mount takes it for you, because none of these attacks ignore shields or mounts, and first hit immunity zeroes it outright.
Dojofive training enemies
Black BeltNORMALno attacks at allSenseiNORMALno attacks at allStraw DummyNORMALno attacks at allWhite BeltNORMALno attacks at allWood DummyNORMALno attacks at all
The Dojo opponent does not fight back. Not one of the five carries a single attack or skill, so it deals no damage at all. The Dojo is scored on the damage you deal, so a defensive slot is wasted there.

9Every normal enemy44 creatures outside the boss fights

The same damage types decide what your runes do here. One row per creature, not per encounter: the game spawns most of these in ones, twos and threes and that changes nothing about what they hit you with. None of these is tagged Boss, so DMG vs Boss is worth nothing against any of them.

EnemyAlso dealsRunes that help
Cave SpiderPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Crystal SlimeIceIcicleMagicalDamagePhysicalDamageBasic Attack DMG Reduction, Ice DMG Reduction, Physical DMG Reduction
Dead SailorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Desert HornetPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Drowned SailorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Fallen AdventurerPhysicalDamageShurikenBasic Attack DMG Reduction, Physical DMG Reduction
Fire SpriteFireMagicalDamageBasic Attack DMG Reduction, Fire DMG Reduction
Fish MonsterPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Ghost KnightCleavePhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Goblin GruntPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Goblin HunterPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Golden WarriorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Hero SpiritPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
ImpPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Living TreePhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Marine FungusPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Mummy WarriorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
PiratePhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Plague StingerPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Red SlimeLifestealPhysicalDamageRageAttackRestorationBasic Attack DMG Reduction, Physical DMG Reduction
SahaginPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
SatyrPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
ScorpionPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
ShroomPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Skeleton ArcherPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Skeleton CommanderComboAttackCounterAttackPhysicalDamageRageAttackBasic Attack DMG Reduction, Combo Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Skeleton HoplitePhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Skeleton KnightPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Skeleton MageMagicalDamageRageAttackBasic Attack DMG Reduction
Skeleton MinerPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Skeleton RingmasterMagicalDamageRageAttackBasic Attack DMG Reduction
Skeleton WarriorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
SkyshroomPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
SlimePhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Snow SpiderPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Snow WolfPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Stone ElementalCounterAttackPhysicalDamageThornsBasic Attack DMG Reduction, Counter Attack DMG Reduction, Physical DMG Reduction
Tribal WarriorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Troll WarriorPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Vile FungusPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Water SpritePhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
WolfPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Wolf SpiderPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction
Zombie ClownPhysicalDamageBasic Attack DMG Reduction, Physical DMG Reduction

Every boss listed here is flagged as a boss encounter in the game files. Damage types come from each attack's own tag list, including the skills a boss carries, not just its basic attack. The BOSS, ELITE and NORMAL tags are the creature's own rank in the game files, which is what DMG vs Boss reads, and it is not the same thing as the fight being a boss fight. Rebuilt from game version 0630.